There is no connection between the level of exposition to statin drugs in the population and the incidence/mortality of acute myocardial infarction: An ecological study based on Sweden's municipalities.Staffan Nilsson, Sigvard Molstad, Catarina Karlberg, Jan-Erik Karlsson and Lars-Goran Persson
Journal of Negative Results in BioMedicine 2011, 10:6 doi:10.1186/1477-5751-10-6
Published: 24 May 2011
Abstract (provisional)
Background
Randomised controlled trials have shown an excellent preventive effect of statins on ischemic heart disease. Our objective was to investigate if a relation can be detected between acute myocardial infarction- (AMI) mortality or incidence and statin utilisation, for men and women in different age-groups on a population basis.
Results
The utilisation rate of statins increased almost three times for both men and women between 1998 and 2002. During 1998-2000 the incidence of AMI decreased clearly for men but only slightly for women. Mortality decreased from 1998 to 2002. The change in statin utilisation from 1998 to 2000 showed no correlation to the change in AMI mortality from 2000 to 2002. Statin utilisation and AMI- incidence or mortality showed no correlations when adjusting for socio-economic deprivation, antidiabetic drugs and geographic coordinates.
Conclusions
Despite a widespread and increasing utilisation of statins, no correlation to the incidence or mortality of AMI could be detected. Other factors than increased statin treatment should be analysed especially when discussing the allocation of public resources.
The results are clear. There is no truth behind the claims of benefit from statins. Even though three times as many Swedish people between ages 40 and 79 were taking statins, there was no reduction in heart attacks. It's unfortunate that the study didn't also investigate the adverse effects caused by them. Then we would know how many people were harmed by these drugs that are known to cause muscle pain and destruction.
The study covered nearly the entire Swedish population aged 40-79 for the years 1998-2000. They included the data from 289 municipalities, which included all areas of the country, urban, suburban, country, industrial, and everything inbetween. The only one left out could not be included because of missing data. The total numbers were 1,926,113 men and 1,995,981 women—a total of 3,922,094 people.
Results from virtually the entire Swedish population demonstrated that the threefold increase in statins use provided no benefit.
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